Abstract:
Objective: To determine the relationship of serial interferon (IFN) measurements and adverse cardiac remodeling (AR) after myocardial infarction (MI). Study Design: Observational multi-centre study. Place and Duration of Study: Departments of Cardiology of Diskapi Yildirim Beyazit Training and Research Hospital, Ataturk Training and Research Hospital, Numune Training and Research Hospital, and Dr. Na z Sincan Korez State Hospital, Turkey, from June 2015 to June 2020. Methodology: Forty-seven patients with acute MI were included. IFN levels were measured on the rst day and at 14 days and 45 days post-MI. Reverse cardiac remodeling (RR) and AR were de ned as the reduction of left ventricular end-diastolic volume by e12% and increases of e12% by cardiac magnetic resonance imaging at the 6-month follow-up. Statistical signi cance was accepted as p<0.05. Results: Median IFN-± (50.1 vs. 34.8 pg/mL, p=0.035), IFN-² (39.1 vs. 23.0 pg/mL, p=0.013), and IFN-³ (26.7 vs. 18.5 pg/mL, p=0.023) levels on the rst day post-MI were higher in the AR group compared to the RR group. At 14 days post-MI, IFN levels had decreased in the AR group, while they had not changed in the RR group. At 45 days post-MI, IFN levels were similar between the AR and RR groups. High IFN-± level on the rst-day post-MI was an independent predictor of AR (OR: 1.23, 95% CI: 1.06-1.43, p=0.008). Conclusion: High IFN levels in the acute phase post-MI are associated with AR. Among IFNs, IFN-± is an important predictor of AR. Stable IFN levels appear to be associated with cardiac healing.
Page(s):
837-842
DOI:
DOI not available
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 7, Year: 2022
Keywords:
Myocardial Infarction
,
In ammation
,
Cardiac remodeling
,
Interferons