Pakistan Science Abstracts
Article details & metrics
No Detail Found!!
An investigation of platelet anti-aggregation activity in indigenous medicinal herbs.
Author(s):
1. Muhammad Anwar Waqar: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
2. Yasir Mahmood: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
3. Asma Saleem: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
4. Sheikh Arshad Saeed: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Abstract:
Platelets play a pivotal role in maintaining blood haemostasis. In present investigation, the platelet aggregation inhibition activity of seventeen (17) indigenous medicinal herbs was studied by using dual-channel aggregometer. The extracts of Medicago saliva, Ficus bengalensis, Allium sativum, Morus alba, Green lea, Boerhavia diffasa, Azadirachta indica, Trigonella foenumgraecum L. Syzygium cumini (Jaman) seeds, Nigella saliva seeds, Peganum harmala, and Moringa oleifera, exhibited significant (PMedicago saliva, Ficus bengalensis, Allium sativum, Morus alba, Green tea, Boerhavia diffusa, Azadirachta indica, Triganella foenumgraecum L, Syzygium cumini (Jaman) seeds, Nigella saliva seeds, peganum harmala, and Moringa oleifera, inhibited ADP-induced aggregation in a concentration--dependent manner. The extracts of Solanum nigrum, Brassica oleracea, Syzygium cumini (Jaman pulp) Cinnamon, Morus fruit, Cyamopsis, Bryophylum, and Tribulus terristris showed relatively less inhibition. Dose response studies of all herbs tested in the present study were also carried out to calculate the concentrations at which 50 % inhibition (IC5o) of platelet aggregation occurred. Our data is indicative that many of these herbs inhibited significant platelet anti-aggregation properties.
Page(s): 324-328
DOI: DOI not available
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 31, Issue: 2, Year: 2009
Keywords:
Keywords are not available for this article.
References:
References are not available for this document.
Citations
Citations are not available for this document.
0

Citations

0

Downloads

4

Views