Abstract:
Background: Allergic diseases affect a large group of population and the common types were asthma, rhinitis, and urticaria and newly found that IL-33 playing an important role in the pathogenicity of allergic diseases. Aim: To evaluate the levels of IL-33 in adult patients has real allergic diseases (asthma, rhinitis, and urticaria) through detection of both positive assays of total and specific IgE of allergic diseases. Methods: The total and specific immunoglobulin E (IgE) and IL-33 were determined in the serum of three types of allergic patients and healthy controls. Results: There were highly significantly higher concentrations of IgE and IL-33 in the serum of patients with allergic diseases. Serum IL-33 and total IgE concentration are clearly statistically highly significant increases in three groups of patients (Rhinitis, Asthma, Urticaria) compared with healthy control (p< 0.001). No significant correlation between IL-33 levels and total IgE in four groups. Conclusion: Our results show a significantly higher concentration in serum level IL-33 of patients with three types of allergic diseases (asthma, rhinitis, and urticaria).
Page(s):
860-862
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 2, Year: 2020