Unilateral Adult Type Granulosa Cell Tumor in Patient with Bilateral Mature Cystic Teratoma Treated with Fertility- Preserving Surgery: A Case Report | [Journal of Pioneering Medical Sciences • 2025]

Author(s):

1. Ala Meshal Aljehani: Department of Pathology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11432 Riyadh, Saudi Arabia

Abstract:

Granulosa Cell Tumor (GCT) of the ovary is a rare, low-grade malignant neoplasm arising from sex cord-stromal cells, accounting for 2-5% of all malignant ovarian tumors. The coexistence of GCT with a mature cystic teratoma is extremely rare, with fewer than ten cases reported in the literature. These mixed tumors present diagnostic and therapeutic challenges due to their distinct origins and biological behavior. We report the case of a 37 year-old premenopausal woman (para one) who presented with acute left lower abdominal pain. Imaging revealed a large left adnexal mass measuring 9.25×8.80×5.90 cm with both solid and cystic components. Surgical management included left salpingo-oophorectomy and right ovarian cystectomy. Histopathological examination confirmed an adult-type granulosa cell tumor of the left ovary coexisting with bilateral mature cystic teratomas. No metastatic spread was observed. This case highlights the rare synchronous occurrence of adult-type granulosa cell tumor with bilateral mature cystic teratomas in a premenopausal woman. Given the indolent nature of GCT and the reproductive age of the patient, fertility-preserving surgery was successfully performed. Awareness of such rare combinations is critical for accurate diagnosis and individualized surgical planning.

Page(s): 16-19

DOI: 10.47310/jpms2025140704

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 14, Issue: 7, Year: 2025

Keywords:

fertility , Teratoma , Ovarian tumours , Granulosa Cell Tumour

References:

[1] Moid ,Robert V.,Jones V.,April 2004 . ."Granulosa cell tumor and mucinous cystadenoma arising in a mature cystic teratoma of the ovary: A unique case report and review of literature.". Annals of Diagnostic Pathology, 8(2) : 96-101.

[2] Alayed ,Abdullah M. . .Ovarian collision tumor, massive mucinous cystadenoma and benign mature cystic teratoma. com/uploads/case_report/pdf/58656/20210806-22430- 1mhsbp4.pdf., 13(7) : .

[3] Färkkilä .2017 .Pathogenesis and treatment of adulttype granulosa cell tumor of the ovary. ” Annals of Medicine, 1294(5) : 435-447.

[4] Nha Pham,Ba Pham .2023 .Fertility‐preserving surgery in a young nulligravid woman with bilateral coexistence of a granulosa cell tumor with a teratoma. ” Case Reports in Obstetrics and Gynecology, 1 : .

[5] Thompson James P. . .Granulosa-cell carcinoma arising in a cystic teratoma of the ovary: report of a case. ” Obstetrics & Gynecology, 28(4) : 549-552.

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