Unique side effects of interferon. | [Journal of Pakistan Medical Association • 2015]

Author(s):

1. Hina Aslam: Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan

2. Rashid Qadeer: Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan

3. Syed Mohammad Kashif: Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan

4. Muhammad Rehan: Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan

5. Salahuddin Afsar: Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan

Abstract:

Interferon-alpha, a potent mediator of host immune response, has immunomodulatory properties in addition to its antiviral effects. A wide spectrum of autoimmune diseases can occur in patients treated with interferonalpha for chronic hepatitis B and D, of which clinical systemic lupus erythematosus (SLE) accounts for less than 1% and hypothyroidismfor 2-4 %.We report herein a case of a 16-year-old male who developed antinuclear antibody (ANA)-negative SLE and hypothyroidism after treatment with interferon-alpha for chronic hepatitis. High index of suspicion is therefore necessary in all patients treated with interferon for early diagnosis and treatment.

Page(s): 895-897

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 65, Issue: 8, Year: 2015

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