Therapeutic Drug Dilemma and Pharmaceutical Mediation in HIV-positive Children in Nigeria University Teaching Hospital. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2017]

Author(s):

1. Shakirat I Bello: Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria

2. ElijahA Adepoju: Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria

Abstract:

Background: In spite of advances in the use of combined antiretroviral drugs in the management of human immunodeficiency virus (HIV) infection, drug therapy problems (DTPs) cause hindrance in the developing countries including Nigeria. Methodology: The DTPs encountered among those children were collected through personal interaction with the children/caregivers, patients' medical folders and PPF. The DTPs observed at baselines were tailed using pharmaceutical interventions at 2 and 4 months. Result: The children studied were mostly males (60.0 %) with a median age of 3.16±0.74 years. Zidovudine backbone regimen was frequently prescribed first-line cART. At baseline, 39.0% of the children had DTPs with an average number of 2.3±4.7 per child. Of the 39.0% DTPs encountered, 6.4% were directly related to PPF. Dosage too low (1.3%), dose not indicated (1.3%), ineffective drugs (1.3%), inappropriate drug adherence (21.3%), adverse drug reactions (10.0%) and dosage too high (3.8%) were the DTPs observed at baseline 0-month. In the last 4th month after pharmacists' intervention, all DTPs were completely resolved among the children including those related to PPF. Conclusion: The pharmacist's mediation in the management of DTPs significantly improved health of the HIV-positive children in this hospital.

Page(s): 49-54

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 5, Issue: 2, Year: 2017

Keywords:

Children , antiretroviral , pharmaceutical intervention

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