Acute interstitial nephritis related to lansoprazole administration. | [Journal of Pakistan Medical Association • 2008]

Author(s):

1. Jimmy Jose: Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal, India

2. Kavitha Saravu: Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal, India

3. Kanav Khera: Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal, India

4. Beena Jimmy: Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal, India

5. Barkur Anantha Krishna Shastry: Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal, India

Abstract:

Acute interstitial nephritis (AIN) is a rare but serious adverse effect reported with proton pump inhibitors (PPIs). Only one report (2 cases) of AIN with lansoprazole is published in literature. A case of lansoprazole induced interstitial nephritis (biopsy supported) was reported in an elderly female patient admitted to the hospital with non specific symptoms after 45 days of treatment with the drug. A recovery was noticed upon withdrawal of the drug and treatment with corticosteroids. We consider this report as a valuable addition to the existing literature on this rare adverse effect with lansoprazole. This potentially serious adverse effect with PPIs including lansoprazole has to be given due consideration, especially taking into account the wide spread use of this group of agents.

Page(s): 206-207

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 58, Issue: 4, Year: 2008

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