To observe the effects of metformin HCl on the carbohydrate metabolism in polycystic ovary syndrome. | [Pakistan Journal of Pharmacology • 2005]

Author(s):

1. N. Karim: Pharmacology and Therapeutics Department, Sindh Medical College, Karachi, Pakistan

2. P. Ahmed Shahida: Pharmacology Department, Faculty of Pharmacy, University of Karachi, Pakistan

3. S. S. Ali: Community Health Sciences, Jinnah Medical and Dental College, Karachi, Pakistan

4. J. A. Hasan: Gynaecology and Obstetrics, Unit-1, Civil Hospital, Karachi, Pakistan

Abstract:

To observe the effects of metformin HCI on the carbohydrate metabolism in polycystic ovary syndrome a clinical trial was carried out on fifty infertile females having polycystic ovary syndrome with ages between 20-40 years. They were enrolled from the infertility clinic of a private hospital in Karachi and were given tablet metformin HCI 500 mg thrice daily for a period of three months. Fasting serum glucose (FSG) and fasting serum insulin (FSI) were done twice during the study period (at day zero and day ninety) to assess the effects on the carbohydrate metabolism. Significant reduction was found in both the FSG and FSI levels at day ninety with P=0.001. It is concluded that metformin has produced beneficial effects on the carbohydrate metabolism in patients having polycystic ovary syndrome. This is because of increase peripheral uptake and utilization of glucose being done by metformin which in turn increases the insulin sensitivity and reduces the insulin resistance in these patients.

Page(s): 61-66

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmacology, Volume: 22, Issue: 2, Year: 2005

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views