Abstract:
Fungal infections represent a threat to human health. Such infections cause conditions that range from athlete's foot to severe disseminated disease. Many fungal diseases like candidiasis or cryptococcosis are continuously spread out as severe health issues throughout the world. Annually, invasive fungal infections cause 1.7 million deaths in the world, which is a major public health issue. Phenothiazines are known to act as potent antifungal agents. Schiff bases are chemical moieties containing an azomethine group (C=N) which also show remarkable antifungal potentials. In search of a synergistic effect, eight novel Schiff bases were synthesized. The synthesized compounds were tested for their antifungal activity. Kirby Bauer disc diffusion method was used to carry out this activity. Four Schiff bases exhibited antifungal potentials against the different fungal strains. Amongst them, STS showed a remarkable activity against most of the strains. The compound SOH also seemed to posses antifungal strength against some species. Furthermore, SAM also exhibited some antifungal effect against four of the species (10mm against Candida albicans, Rhizomucor pusillus and Aspergillus fumigates; 13mm against Aspergillus flavus). SDN showed activity (10mm) against Aspergillus niger. It is note-worthy to mention that on this strain, even the standard antifungal drug, fluconazole, was seen devoid of any antifungal potential. Since Schiff bases metal complexes are proved to posses excellent antifungal potentials, further activity of these four compounds can be enhanced by their nanosynthesis.
Page(s):
158-158
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023