A randomized study of an evaluation of Trigona honey as immunonutrition among ventilated pneumonia patients in intensive care unit | [Anaesthesia, Pain and Intensive Care • 2022]

Author(s):

1. Rhendra Hardy Mohamad Zaini: Department of Anesthesiology & Intensive Care, School of Medical Sciences & Hospital,E -mail:,Malaysia;

2. Sanihah Che Omar: Department of Anesthesiology & Intensive Care, School of Medical Sciences & Hospital,E -mail:,Malaysia;

3. Isma Syarina Binti Ismail: Department of Anesthesiology & Intensive Care, School of Medical Sciences & Hospital,E -mail:,Malaysia;

4. Wan Mohd Nazaruddin Wan Hassan: Department of Anesthesiology & Intensive Care, School of Medical Sciences & Hospital, Health Campus, Universiti Sains Malaysia (USM), 16150 Kubang Kerian, Kelantan, Malaysia;

5. Praveena Seevaunnamtum: Department of Anesthesiology & Intensive Care, School of Medical Sciences & Hospital, Health Campus, Universiti Sains Malaysia (USM), 16150 Kubang Kerian, Kelantan, Malaysia

6. Che Maraina Che Hussin: Department of Immunology, School of Medical Sciences, Health Campus, University Sains Malaysia (USM), 16150, Kubang Kerian, Kelantan, Malaysia

Abstract:

Background & Objective: Honey is one of the traditional drugs and has been widely used as a nutrient supplement for centuries. It is known to have antimicrobial, antioxidant and radical scavenging properties. We aimed to prove that natural honey can be added as a supplementary nutrient for its immunoprotective effects to the ventilated pneumonia patients in intensive care unit (ICU). Methodology: A total of 40 ventilated pneumonia patients were randomized to receive enteral feeding with honey (n = 20) or without honey (n = 20). A bolus of 20 g of honey was given every day for 5 days together with normal enteral nutrition. The baseline vital signs, ventilator settings, blood samples for C-reactive protein (CRP), white blood cell (WBC), interleukin-6 (IL-6), interleukin-10 (IL-10), immunoglobulin A (IgA) and blood sugar level were taken on the day of recruitment (Day 0) and subsequently on Day 3 and Day 6. Results: There were significant changes in IL-6 level over time in honey group with mean decrease of IL-6 from 265.1 pg/ml on Day 0 to 101.8 pg/ml on Day 6 (P 0.05). Duration of antibiotic use between the two groups showed no statistically significant difference with P = 0.075 and length of ICU stay. Conclusion: Trigona honey showed the beneficial effect of immunonutrition to ventilated pneumonia patients in ICU by significantly decreasing the level of IL-6.

Page(s): 649-655

DOI: 10.35975/apic.v26i5.1990

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 26, Issue: 5, Year: 2022

Keywords:

pneumonia , Interleukin6 , Interleukin10 , Immunonutrition , Trigona Honey

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