The relationship of oxidative stress and inflammatory response in females associated with endometriosis | [Pak-Euro Journal of Medical and Life Sciences • 2022]

Author(s):

1. Sumera Noor: Department of Allied Health Sciences, The Superior University, Lahore, Pakistan

2. Tahir Muhammad: Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan

3. Mateen-Ur- Rehman: Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan

4. Bushra Sayyed: Department of Gynaecology and Obstetrics, Sir Ganga Ram Hospital /Fatima Jinnah Medical University, Lahore, Pakistan

5. Shahid Noor: Department of Allied Health Sciences, The Superior University, Lahore, Pakistan

6. Jan Ubaidullah: Department of Allied Health Sciences, The Superior University, Lahore, Pakistan

7. Tahir Maqbool: Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan

8. Rana Muhammad Athar Azeem Shams: Department of Allied Health Sciences, The Superior University, Lahore, Pakistan

Abstract:

Endometriosis is considered as a debilitating condition that is characterized by formation of endometrial tissue outside the uterus that consequently adversely impacts female fertility. Number of factors are involved that mediates the gynecological pathology of endometriosis, however the relationship of endometriosis with oxidative stress and inflammatory needs to investigate. In this study, we selected females of age 21-27 years associated with endometriosis and performed a detailed hematological profile. Our data indicated that the hematological profile of patients associated with endometriosis was highly disrupted compared to healthy control females. Number of hematological parameters including RBCs, WBCs, HB, platelets and overall bilirubin level was abnormal in endometritis patients. In addition, we also determined the level of oxidative stress by using the expression profile of different oxidant and antioxidant genes through spectrophotometric examination. We found elevated levels of MDA and reduced expressions of SOD, GSH, and CAT in patients associated with endometriosis relative to healthy patients that suggest the increased oxidative stress level. Furthermore, different vitamins including, Vit. A, Vit. C, VIit. E and Vit. D levels were also reduced in patients of endometriosis. Collectively, our data suggest that hematological profile and oxidative stress of patients associated with endometriosis was highly disruptive and these differential biomarkers may be useful to diagnose the endometriosis patients and also beneficial for developing treatment strategies.

Page(s): 345-350

DOI: 10.31580/pjmls.v5i2.2523

Published: Journal: Pak-Euro Journal of Medical and Life Sciences, Volume: 5, Issue: 2, Year: 2022

Keywords:

RBCs , Platelets , oxidative stress , hemoglobin , Endometriosis , Hematocrit , WBCs

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