An Improved Method of Synthesis of Per-6-deoxy-6-iodo-ß-cyclodextrin. | [Journal of Chemical Society of Pakistan • 2019]

Author(s):

1. Suomin Feng: Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi'an Medical University, No. 1, Xinwang Road, Xi’an, Shaanxi, PR China

2. Jiaxing Feng: Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi'an Medical University, No. 1, Xinwang Road, Xi’an, Shaanxi, PR China

3. Guangcan Xu: Sorbonne University, CNRS, IPCM, UMR 8232, 4 place Jussieu, Paris, France

4. Jiang Liu: Sorbonne University, CNRS, IPCM, UMR 8232, 4 place Jussieu, Paris, France

5. Yongmin Zhang: Sorbonne University, CNRS, IPCM, UMR 8232, 4 place Jussieu, Paris, France

Abstract:

Summary: A number of per-6-substituted-6-deoxy-ß-cyclodextrin derivatives have been synthesized for many years, of them, per-6-deoxy-6-iodo-ß-cyclodextrin is of great importance in supramolecular chemistry. By reviewing all published papers related to synthesis of per-6-deoxy-6-iodo-ß-cyclodextrin and combining with our experimental verification, this work has reported an improved method of synthesis of per-6-deoxy-6-iodo-ß-cyclodextrin. The approach mainly uses adding a certain amount of methanol instead of removing DMF before adjusting pH. We think this project is simple, efficient, high repeatable and suitable for large-scale preparation, superior even to all the previously reported methods. The synthesis of bromo, chloro substituted -per-6-ß-CD may also refer to this improved method. At the same time, the detailed introduction of operation process and precautions will serve as a reference and guidance to the beginner who will engage in the study on the chemical synthesis reaction of sugar and cyclodextrin.

Page(s): 356-362

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 41, Issue: 2, Year: 2019

Keywords:

Keywords are not available for this article.

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