Analgesic and neuropharmacological activities of Berberis lycium Royle collected from district Sherani Balochistan, Pakistan | [Pakistan Journal of Pharmaceutical Sciences • 2020]

Author(s):

1. Samiullah: Department of Pharmacology, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

2. Javied Iqbal: Department of Pharmacology, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

3. Amanullah Khan: Provincial drug testing laboratory,Quetta, Balochistan,Pakistan

4. Shafi Muhammad: Department of Pharmcognosy, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

5. Marvi: Department of Pharmacology, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

6. Syed Umer Jan: Department of Pharmaceutics, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

7. Rahman Gul: Department of Pharmaceutics, Faculty of Pharmacy and Health Sciences, University of Balochistan,Quetta,Pakistan

Abstract:

Berberis lycium (family Berberidaceae) grows in district Sherani, Balochistan, Pakistan. It is used for the treatment of various disorders by the people of Balochistan. The present work was carried out to explore analgesic and neuropharamcological activities of crude methanolic extracts of B. lyceum. The analgesic activity was carried out by acetic acid induced writhing test and formalin test. Open field test, cage crossing test, rearing test, traction test and forced swimming test were carried out in neuropharmacological activities. The results reveal that crude methanolic extracts of B. lyceum showed significant (P<0.05) analgesic activity in acetic acid induced pain as well as with formalin test. In neuropharmacological activities, crude methanolic extracts of B. lyceum showed significant (P<0.05) central nervous system depressant activity and in forced swimming test it showed anxiolytic effects.

Page(s): 1689-1695

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: 4, Year: 2020

Keywords:

analgesic , Balochistan , Berberidaceae , Berberis lyceum

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