A single-nucleotide polymorphism in the osteopontin gene 9250 contribute to susceptibility to ankylosing spondylitis. | [Pakistan Journal of Zoology • 2016]

Author(s):

1. Peng Tian: Department of Orthopedics, Yichang Yiling Hospital, Yichang, Hubei Province, China

2. Zhaoqing Zhang: Department of Rehabilitation and Pain, The Third Hospital of Wuhan, Wuhan, Hubei Province, China

3. Qiaomei Liu: Department of Rehabilitation and Pain, The Third Hospital of Wuhan, Wuhan, Hubei Province, China

Abstract:

The aim of this study was to investigate possible association of a single nucleotide polymorphism (SNP) at position 9250 in exon 7 of the Osteopontin gene (OPN gene 9250) with ankylosing spondylitis (AS). A case–control association study was performed in 120 AS patients and 106 matched controls, consented to participate in the study. OPN gene 9250 polymorphism was detected by polymerase chain reaction (PCR) and direct sequencing. The frequency of the TC+CC genotype of the OPN gene 9250 was significantly higher (25.83% vs 12.26%, p

Page(s): 1753-1756

DOI: DOI not available

Published: Journal: Pakistan Journal of Zoology, Volume: 48, Issue: 6, Year: 2016

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