A trap in measuring of plasma digoxin level after stoping of a treatment. | [Pakistan Heart Journal • 1995]

Author(s):

1. Zijad Durakovic: Internal Medicine Department, Rebro University Hospital, Medical Faculty University of Zagreb, Croatia

2. Senadin Durakovic: Internal Medicine Department, Rebro University Hospital, Medical Faculty University of Zagreb, Croatia

3. Naima Corovic: Internal Medicine Department, Rebro University Hospital, Medical Faculty University of Zagreb, Croatia

4. Ibrahim Ramic: Internal Medicine Department, Rebro University Hospital, Medical Faculty University of Zagreb, Croatia

Abstract:

In this paper, a course of the disease of a 68-year-old patient treated with medigoxin for congestive heart failure is presented. After being withdrawn from his treatment at the hospital, the patient was administered spironolactone and furosemide. The plasma digoxin level at entry was 1. 1 nmol/L, after five days it reached 3. 2 nmol/L, and after ten days was 2. 3 nmol/L. The patient had a normal renal function. The interference of spironolactone and its metabolites with the digoxin radioimmunoassay was discussed as a possible explanation for this phenomena.

Page(s): 50-52

DOI: DOI not available

Published: Journal: Pakistan Heart Journal, Volume: 28, Issue: 3--4, Year: 1995

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