8-hydroxydeoxyguanosine levels, periodontitis in smoker and non-smoker: A pilot study. | [Journal of Pakistan Dental Association • 2006]

Author(s):

1. Balwant Rai: Government Dental College, Pt. bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, rohtak, Haryana, India

2. S. C. Anand: Government Dental College, Pt. bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, rohtak, Haryana, India

3. Rajnish Jain: Dental Wing Maulana Azad Medical College, New Delhi, India

4. Simmi Kharb: Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Science, Rohtak, Haryana, India

Abstract:

To determine the association between levels of a marker of oxidative stress, 8-hydroxydeoxyguanosine (S-OHdG), in saliva and presence ofperiodontitis in smokers and non-smokers. Forty subject samples, as healthy control (n=16), periodontitis in smokers (n=11) and periodontitis in non-smokers (n=13) were recruited for the study. The 8-OHdG was analyzed in the saliva of smoking and non-smoking patients of periodontitis and healthy control. Salivary levels of 8-OHdG were significantly higher in subject with periodontitis who smoked as compared to non-smoker (6.82 + 0.18 ng/ml and 4.83 + 0.16 ng/ml). Thus, measurement of 8-OHdG may prove to be useful in identifying periodontal disease and risk of tooth loss.

Page(s): 89-90

DOI: DOI not available

Published: Journal: Journal of Pakistan Dental Association, Volume: 15, Issue: 2, Year: 2006

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