The intracerebroventricular (ICV) administration of w-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats. | [Pakistan Journal of Pharmaceutical Sciences • 2010]

Author(s):

1. Gholamreza Sepehri: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

2. Vahid Sheibani: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

3. Afrooz Azarang: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

4. Mohammad Reza Afarinesh: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

5. Ali Shamsizadeh: Department of Physiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

6. Saeed Azizollah: Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

7. Ehsan Sepehri: Tehran University of Medical Sciences, Tehran, Iran

Abstract:

The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W- 7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 μmol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 μmol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.

Page(s): 170-174

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 23, Issue: 2, Year: 2010

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