Abstract:
Purpose of investigation is to understand the causal role of antipsychotics [Haloperidol (HAL) and Clozapine (CLZ)] in the management of Schizophrenia and the contribution of Sea Buckthorn (SBT) in the attenuation of antipsychotic-induced motor impairments in rats. Schizophrenia is a psychotic illness followed by abnormal increase in levels of dopamine. Antipsychotic medications have been used for the treatment of psychosis but are associated with extrapyramidal symptoms (EPS). SBT fruit extract may serve as an adjuvant in the eradication of EPS. For this investigation twenty-four (n=24) male Albino Wistar rats, weighted 180±20g were used. Animals categorized into two equal groups (n=12), were treated with water (WAT) and SBT for two-weeks. Both groups were subdivided into six equal groups (n=4): two control groups (n=4), pre-treated with WAT and SBT were injected with 0.9% NaCl; Two groups, pre-treated with WAT were intraperitoneally injected with CLZ and HAL (2.5 mg.kg-1); two groups, pre-supplemented with SBT (50 mg.kg-1) were injected with HAL and CLZ (2.5 mg.kg-1) followed by the oral supplementation of SBT for 10 days. After effects of CLZ, HAL and SBT were depicted by behavioral and physiological assessments at 1st, 5th and 10th day from 10 to 15 mins post injection. Open field activity depicted the significantly increased (p<0.01) exploratory activity in the group of animals supplemented with SBT as compared to the group animals injected with HAL and CLZ.Motor incoordination via Rotarod Performance Test depicted significantly increased (p<0.01) in the group of animals treated with SBT. Haloperidol more provoke the development of extrapyramidal symptoms coupled with stereotyped behavior and motor incoordination. Sea Buckthorn has remarkable antipsychotic effects that may lead to a future drug discovery for the management of Schizophrenic patients.
Page(s):
DOI:
DOI not available
Published:
Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023