Antibiotics Residues and Resistance Genes in Agroecosystem: Sustainable Approaches for Mitigation and Management | [1st International Conference on "Recent Advances in Green Biotechnology and Climate Resilience", September 15-16, 2025 • 2025]

Author(s):

1. Sardar Khan: Deptt. of Environmental Sciences, University of Peshawar; Deptt. of Environmental Sciences, SBB University Dir; Deptt. of Environmental Sciences, Kohat University of Science and Technology, Kohat, Pakistan.

2. M. Idress: Deptt. of Environmental Sciences, University of Peshawar; Deptt. of Environmental Sciences, SBB University Dir; Deptt. of Environmental Sciences, Kohat University of Science and Technology, Kohat, Pakistan.

3. Ajmal Khan: Deptt. of Environmental Sciences, University of Peshawar; Deptt. of Environmental Sciences, SBB University Dir; Deptt. of Environmental Sciences, Kohat University of Science and Technology, Kohat, Pakistan.

4. Juma Muhammad: Deptt. of Environmental Sciences, University of Peshawar; Deptt. of Environmental Sciences, SBB University Dir; Deptt. of Environmental Sciences, Kohat University of Science and Technology, Kohat, Pakistan.

5. Palwasha Khan: Deptt. of Environmental Sciences, University of Peshawar; Deptt. of Environmental Sciences, SBB University Dir; Deptt. of Environmental Sciences, Kohat University of Science and Technology, Kohat, Pakistan.

Abstract:

The widespread use of ABs in livestock farming has led to the accumulation of Abs residues and ARGs in agricultural soil, which poses severe threats to environment and public health. TCs, SAs, MCs, FQs and ß-L are widely used in veterinary medicine and are excreted in feces, serving as major vectors forARGs such as tetA, tetG, ermB, sul1, qnrS and blaTEM. The genes tetG andtetAP predominantly contribute to TCs resistance by encoding efflux pump mechanisms. In contrast, sul1 and sul2 showed strong correlations with soil salinity which promote the persistence of ARGs in environment. Manure application can increase ARGs abundance over a period of decades, with erm Breaching 7.29 × 109 copies/g in manure and qnrS persisting in soil fertilized for30 years. These ARGs can further disseminated through HGT and amplified byintegrase genes. Innovative material such as BCs NPs, MOFs and COFs have proven their ability to mitigate these risks. BCs adsorbs 39% of OTC uptake in lettuce and suppress ARGs by altering microbial communities. NPs such as Ag,ZnO and Fe based NPs degrade ABs through photo catalysis (94.9%) and disrupt bacterial membranes (inhibiting HGT). MOFs such as MIL-100(F) achieved96.6% degradation of levofloxacin while COFs (TpBD-(CF3)2 showed exceptional adsorption efficiency (3387%, recovery rate) for sulpha pyridine and capacities ranged from 68.8-196.7 mg g-1 for FQs. Despite these advances, challenges remain including material stability, environmental impacts, and scalability. Future efforts should focus on optimizing feedstock’s for BCs, ecofriendly NPs synthesis and MOFs/COFs composites with enhanced light absorption properties. Integrating these materials with sustainable practices and enforcing manure management regulations are critical to reduce the ARGs Proliferation. Addressing this crisis requires interdisciplinary cooperation to Safeguard agro ecosystems.

Page(s): 42-42

DOI: DOI not available

Published: Journal: 1st International Conference on "Recent Advances in Green Biotechnology and Climate Resilience", September 15-16, 2025, Volume: 1, Issue: 1, Year: 2025

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