A Case Study of an Inflammatory Breast Cancer in Men-lobular Subtype | [Journal of Pioneering Medical Sciences • 2025]

Author(s):

1. Alaa Abdulrahman Marzogi: Department of Radiology, King Abdullah Medical City, Makkah, Saudi Arabia

2. Reem Mohammed Noor Kalakattawi: Department of Radiology, Alhada armed forces hospital-Taif, Saudi Arabia

3. Athal Kamal Filemban: Department of Radiology, King Abdullah Medical City, Makkah, Saudi Arabia

4. Amani Mohammad Abbad Alwadei: Department of Radiology, King Khaled Hospital, Najran, Saudi Arabia

Abstract:

Objectives: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, accounting for 1-5% of all breast malignancies. Male breast cancer is particularly uncommon, comprising less than 1% of all cases and IBC in males presents even greater diagnostic and therapeutic challenges. This case study highlights a 49-year-old Sudanese male diagnosed with inflammatory breast cancer of the lobular subtype. The patient initially presented with a palpable right breast mass and nipple discharge, without characteristic skin changes often associated with IBC. Diagnostic imaging and biopsy confirmed infiltrating lobular carcinoma, characterized by estrogen receptor positivity (ER+), HER-2 overexpression and a Ki-67 index of 30%. Despite treatment delays, the patient underwent four cycles of palliative chemotherapy, achieving a significant reduction in tumor burden. However, complications such as axillary lymphedema and pleural effusion emerged during treatment. Followup evaluations, including imaging and clinical assessments, demonstrated no palpable masses or axillary lymphadenopathy, suggesting a favorable response to therapy. This case underscores the importance of early detection and multidisciplinary management in improving outcomes for male IBC patients. The findings emphasize the necessity for heightened awareness of male breast cancer, particularly rare subtypes like lobular IBC, among healthcare providers. Moreover, this case contributes valuable insights into the clinical presentation, diagnostic strategies and treatment outcome.

Page(s): 8-14

DOI: 10.47310/jpms2025140102

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 14, Issue: 1, Year: 2025

Keywords:

HER2 positive , Lobular carcinoma , Inflammatory breast cancer , rare cancer cases , diagnostic challenges , male breast cancer , palliative chemotherapy

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