Therapeutic efficacy of intravenous magnesium sulphate for the treatment of acute asthma in the Emergency Department | [Pakistan Journal of Surgery • 2021]

Author(s):

1. Wajahat Ali: Dr. Ziauddin University & Hospital, Karachi, Pakistan

2. Shua Nasir: Dr. Ziauddin University & Hospital, Karachi, Pakistan

3. Lal Shahbaz: Dr. Ziauddin University & Hospital, Karachi, Pakistan

4. Mohammed Aqil: Dr. Ziauddin University & Hospital, Karachi, Pakistan

5. Syed Jehanzeb Asim: Dr. Ziauddin University & Hospital, Karachi, Pakistan

6. Abdul Samad: Dr. Ziauddin University & Hospital, Karachi, Pakistan

Abstract:

is real. Background: Acute asthma management is based on rapid reversal of bronchospasm and reduced infl ammatory mucosa of airway. Th e age old solution i.e. nebulization with ß agonist therapy, is increasingly being with discouraging results in moderate to severe asthmatics. Since the “poor responders” comprise up to 30% of all acute asthmatics, the need for newer options Objective: To study the therapeutic efi cacy of magnesium sulphate (intravenous) for the treatment of acute asthma in the emergency department. Material and Methods: Sample of 100 patients taken for this study from 1st January 2020 till 31st December 2020. with acute exacerbation of asthma, this is a prospective cohort study. No any bias was noticed related to gender or age.and the sample was collected using non-probability, consecutive sampling. Simple clinical assessment was done for the entire sample and oxygen saturation along with peak expiratory fl ow rate before and aft er the intervention were recorded in addition to basic biodata and socio-demographic details and disease particulars. hT e patients were randomly designated into two groups-A (Intravenous placebo infusion of normal saline) and B (Intravenous infusion of 1.2g magnesium sulphate) aft er conventional ß agonist therapy failed to produce signifi cant improvement in peak expiratory fl ow rate. Th e data was recorded in proforma and analyzed using SPSS v.21. & Microsoft Excel. Results: 112-patients were enrolled, in this study males were 63.4% & 36.6% were females. hT e mean age is 44 years (SD ± 13.11) and most (33.03%) of the patient were aged 56 and above. Th e group was taking treatment reveals an elevation in peak expiratory fl ow rate from 212 to 293 L/min in comparison with 202 to 219 L/min in the placebo group. In addition, hT e ratio was signifi cantly improved in treatment group in comparison with placebo group in admit ed vs discharged. Conclusion: Aft er careful consideration, it can be concluded that the intravenous magnesiumsulfate has high therapeutic efi cacy when used in for acute episodes of moderate to severe asthma in patients that respond poorly to conventional nebulized ß-agonist therapy.

Page(s): 196-199

DOI: DOI not available

Published: Journal: Pakistan Journal of Surgery, Volume: 37, Issue: 3, Year: 2021

Keywords:

Acute Asthma , peak expiratory volume , emergency medical care , intravenous magnesium sulphate and ßagonist therapy

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