The role of thrombofilia related tofactor V leiden and factor II G20210A mutations in recurrent abortions. | [Journal of Pakistan Medical Association • 2005]

Author(s):

1. Muge Aksoy: Departments of Obstetrics, Ankara University School of Medicine Cebeci, Sihhiye, Ankara, Turkey

2. Bulent Berker: Departments of Obstetrics, Ankara University School of Medicine Cebeci, Sihhiye, Ankara, Turkey

3. Feride Soylemez: Departments of Obstetrics, Ankara University School of Medicine Cebeci, Sihhiye, Ankara, Turkey

4. Ibrahim Tek: Gynecology, Medical Oncology, Ankara University School of Medicine Cebeci, Sihhiye, Ankara, Turkey

5. Halil Karabulut: Medical Biology and Genetics, Ankara University School of Medicine Cebeci, Sihhiye, Ankara, Turkey

Abstract:

Objective: To study, the impact of thrombophilia caused by Factor V, Factor II G20210A mutations on recurrent abortions, the prevelance of Factor V Leiden and Factor II G20210A mutation in patients with habitual abortions. Methods: Forty one patients with a diagnosis of habitual abortion were enrolled in the study. Control group consisted of 50 women without a history of poor obstetric outcome. 10 ml. peripheral venous blood was taken from study and control groups and transferred to EDTA tubes, and were tested for Factor V Leiden and Factor II G20210A mutations by PCR in genetics laboratory. Results: Phenotypes of 91 cases were determined by PCR for Factor V Leiden. It was established that of 41 patients in the study group, 31 (75.6%) had GG genotype, 9 (22%) had GA genotype and 1 (2.4%) had AA genotype. In the control group, 45 (90%) of 50 women had GG genotype and 5 (10%) had GA genotype. A allele carrier status was found to be 24.4% in study group and 10% in the control group. The difference between them was not statistically significant (p=0.06). Conclusions: The results obtained from patients and control group have no difference in Factor V Leiden and Factor II G20210A mutations.These results suggest that mutations have no role in etiology of 1 and 2 trimester recurrent abortions.

Page(s): 104-108

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 55, Issue: 3, Year: 2005

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