A-Chymotrypsin and Urease inhibitory activity of Diversolides C, D and E from the roots of Ferula diversivittata. | [Journal of Chemical Society of Pakistan • 2012]

Author(s):

1. Saleha Suleman Khan: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

2. Ajmal Khan: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

3. Bishnu P. Marasini: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

4. Viqaruddin Ahmad: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

5. Muhammad Iqbal Choudhary: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

6. Nikhat Saba: Department of Chemistry, Jinnah University for Women, 5-C, Nazimabad, Karachi-74600, Pakistan; Department of Pharmacognosy school of pharmacy, P.O.Box 91775-1365, Mashhad University of Medical Sciences, Mashhad, Iran

7. Mehrdad Iranshahi: Department of Pharmacognosy school of pharmacy, P.O.Box 91775-1365, Mashhad University of Medical Sciences, Mashhad, Iran

8. Seyyed Tahmineh Hosseini: Department of Pharmacognosy school of pharmacy, P.O.Box 91775-1365, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Sesquiterpene lactone derivatives, diversolides-C (giferolide) (1), -D (malafilin) (2), and -E (fegvolide) (3), isolated from the roots of Ferula diversivittata, Regel. & Schmalh, were evaluated for a-chymotrypsin and urease inhibition activities. Diversolide-E (3) was found to be a moderate inhibitor against both enzymes while all others were found to be inactive. The IC50±SEM values of 3 were 388.2±1.7 µM, and 116.0±4.8 µM for α-chymotrypsin and urease, respectively.

Page(s): 699-701

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 3, Year: 2012

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