Unleashing Nature`s Potential: Herbal Extracts as a Promising Therapy for Drug-Resistant Epilepsy | [Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 • 2023]

Author(s):

1. M. Wasim: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

2. Mehr Mussani: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

3. Syeda Arfa: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

4. Hasan Salman Siddiqi: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

5. Saara Ahmad: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

6. Fazal Manzoor Arain: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

Abstract:

Epilepsy is a neurological disorder in which the patient suffers with two or more unprovoked seizures. Temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) is the most common form of drug resistant epilepsy. Therefore, new treatment options are required for TLE-HS. Herbal extracts obtained from Zingiber officinale and Carum Carvi are promising treatment option for TLE-HS. In the current study, Sprague Dawley rats are used as a model of TLE-HS to test the efficacy of herbal extracts. Lithium-Pilocarpine treatment on rats has been used to develop rodent model for TLE-HS for over 40 years. Briefly, Lithium-Pilocarpine is injected intra-abdominally to induce seizures in rats for 1 hour. After that the rats are allowed to recover for 2 weeks. During this time hippocampal sclerosis occurs. After this treatment the rats have spontaneous recurrent seizures at a frequency of 6-7/ week for the rest of their lives. After two weeks, we treated the rats with herbal extract daily for next one and half month. After this the rats were tested for short-term memory loss and depression using behavioral test, which included novel object recognition test and forced swim test. After the completion of these tests, the rats were sacrificed and transcardial perfusion with 4% PFA was performed to conduct nissl staining on brain slices of rats. Our preliminary results have shown that Zingiber officinale extract reduces the frequency of seizures, improves memory, and reverses the sclerosis of hippocampus in TLE-HS model of rats.

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Published: Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023

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