Abstract:
This comparative study was designed to assess the efficacy of zolmitriptan, a triptan widely employed as first-line therapy for migraine, in relieving post-dural puncture headache in parturients who were operated for cesarian section under spinal anesthesia. Methodology: The study was carried out at department of Anesthesiology, Combined Military Hospital Rawalpindi, over a period of twelve months from August 2012 to July 2013. We enrolled 60 adult parturients who complained of post-dural puncture headache in post-partum period. They were divided into two equal groups of 30 each; Group-1 (Z-group) received zolmitriptan along with other supportive treatment for spinal headache and Group-2, control group (C-group) was given only supportive treatment. Efficacy of zolmitriptan in relieving post-dural puncture headache (PDPH) was studied and frequency of complications of the drug were noted. Results: After 6 hours, 60% patients of Z-group got relief from headache. While in control group only 36.66% patients were pain free (p 0.016). After 12 hours, relief from headache was noted in 70% patients of zolmitriptan-group while in C-group only 46.66% were relieved (p 0.015). After a period of 24 hours results were 86.66% vs. 63.33% (p 0.006). After 48 hours, in Z-group 96.66% patients were pain free, while in C-group 63.33% were free from headache (p 0.001). There was no change in results for Z-group after 72 hours. In contrast, in C-group 80% were pain free and 20% patients were still symptomatic. Borderline statistical significance was present (p 0.046). Conclusion: The study revealed that anti-migraine drug zolmitriptan in combination with supportive treatment is effective in relieving PDPH in parturients.
Page(s):
147-151
DOI:
DOI not available
Published:
Journal: Anaesthesia, Pain and Intensive Care, Volume: 18, Issue: 2, Year: 2014