A novel therapy of combination Fractional CO2 Laser with topical insulin for treating atrophic acne scar: Single arm study | [Journal of Pakistan Association of Dermatologists • 2024]

Author(s):

1. Yuli Kurniawati: Department of Dermatology Venereology and Aesthetics, Mohammad Hoesin General Hospital/ Faculty of Medicine Sriwijaya University,Palembang,Indonesia

2. Sarah Diba: Department of Dermatology Venereology and Aesthetics, Mohammad Hoesin General Hospital/ Faculty of Medicine Sriwijaya University,Palembang,Indonesia

3. Kiki Septiafni: Department of Dermatology Venereology and Aesthetics, Mohammad Hoesin General Hospital/ Faculty of Medicine Sriwijaya University,Palembang,Indonesia

4. Rina Novriani: Department of Dermatology Venereology and Aesthetics, Mohammad Hoesin General Hospital/ Faculty of Medicine Sriwijaya University,Palembang,Indonesia

5. Wenty Septa Aldona: Department of Dermatology Venereology and Aesthetics, Mohammad Hoesin General Hospital/ Faculty of Medicine Sriwijaya University,Palembang,Indonesia

6. Monica Trifitriana: Medical Education Study Program, Faculty of Medicine, Sriwijaya University,Palembang,Indonesia

Abstract:

Introduction Atrophic acne scars pose significant cosmetic and psychological challenges for individuals. Various treatment modalities have been explored, including fractional CO2 laser therapy and topical insulin, which have shown promising efficacy in scar remodelling and tissue regeneration. The objective of the study is to evaluate the effectiveness and safety of a novel therapy utilizing a combination of fractional CO2 laser and topical insulin in treating atrophic acne scars. Methods A total of 19 patients with atrophic acne scars in Palembang were enrolled in this study. The treatment regimen included a combination of fractional CO2 laser therapy and topical insulin application. Treatment sessions were performed once every two weeks for two months. Scar severity was assessed using validated scales, and patient satisfaction and adverse events were recorded. Results The combination of fractional CO2 laser and topical insulin therapy demonstrated promising results in treating atrophic acne scars with significant developments in all outcome variables (Goodman and Baron score, visual analog scale, and quality of life index in dermatology). Significant improvements in scar severity and patient satisfaction scores were observed at the end of the treatment period (at six weeks), with minimal reported adverse events. There is no significant result for random blood sugar with topical insulin influencing blood sugar systemic. Conclusion A combination of fractional CO2 laser and topical insulin therapy has been proven effective in treating acne atrophic scars. This treatment option shows promise for managing acne atrophic scars due to its effectiveness and safety.

Page(s): 400-407

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 2, Year: 2024

Keywords:

fractional CO2 laser , Abstract , novel therapy , Atrophic scar , Palembang , Topical insulin

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