Abstract:
Effect of thioacetamide (TAA)on the body weight, kidney weight and the total nucleic acids content of kidney of mouse were studied. TAA 1% and 2% solutions were injected intraperitoneally, twice with an interval of 24 hours, in two different batches of male mice. In this way one batch received a total, dose of 100 mg TAA/Kg body weight while the other got a total dose of 200 mg TAA/Kg body weight. Both the body was well as kidney weights decrease after TAA treatment. A total dose of 200 mg/kg body weight is a stronger inhibitor of growth as compared with that of 100 mg/kg body weight. The nucleic acids content show an increase after the drug treatment. The ribonucleic acid content of kidney increased from an average value of 4.30 + 0.14 mg/gm kidney to 4.60 + 0.22 mg/gm kidney after 1% TAA treatment. The increase in 2% TAA treated mice is slightly more prominent. The deoxyribonucleic acid (DNA) contents of kidney are likewise affected. After an initial increase in 1% TAA treated animals, the DNA content gradually fall down to normal control values. Administration of 2% TAA solution causes an average increase of 21% i.e. from 1.93 + 0.19 mg/gm kidney weight to 2.26 + 0.23 mg/gm kidney weight. The size of cell, nucleus and nucleolus also increased after drug treatment, which mainly occurred during the first 24 hours of the post-treatment period.
Page(s):
41-47
DOI:
DOI not available
Published:
Journal: Nucleus, Volume: 13, Issue: 3, Year: 1976