Abstract:
Graphene scaffolds have spectacular drug delivery properties such as small size, high surface area, layer number, lateral dimension, surface chemistry and purity, improved physicochemical properties surface and intrinsic antibacterial activates. Consequently, it has gained broad interests in delivery of small molecule for instance drug and gene. The current study deals with fabrication of GZnO-CHDEXscaffolds which were prepared through Layer-by-layer method using polymeric hybrid of chitosan and dextran and consequently was used for delivery of topical antibiotic bacitracin. These nano composites were characterized by UV-Vis, FTIR spectroscopy, zeta potential, DLS, TGADSC, SEM and XRD. The in-vivo wound healing potential of the drug loaded G-ZnOnanoconjugates gel was analyzed in Sprague–Dawleyratsat different time points (day 1, 3, 6, 9, 12 & 14) that showed at day 15, 56% wound contraction was observed compared to the control which showed 45% contraction, enhanced cell adhesion, epithelial migration, and high hydroxyproline content leading to faster and more efficient collagen synthesis compared to reference marketed product, placebo (vehicle) and negative control resulting in complete wound healing with no scar formation. Thus, novel delivery strategy of BCT loaded graphene based CH / DEX nanoconjugates gel has therapeutic potential in effective management of wound and scar less healing.
Page(s):
37-37
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Graphene scaffolds
,
bacitracin
,
invivostudies
,
scars less wound healing