Acute Hepatitis E Viral Infection in Pregnancy and Maternal Morbidity. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2015]

Author(s):

1. Meharun Nissa Khaskheli: Department of Obstetrics and Gynaecology, Government Employees Cooperative Housing Society (GMB Colony), Qasimabad, Hyderabad, Pakistan

2. Shahla Baloch: Department of Obstetrics and Gynaecology, Government Employees Cooperative Housing Society (GMB Colony), Qasimabad, Hyderabad, Pakistan

3. Aneela Sheeba: Department of Radiology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan

4. Sarmad Baloch: Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan

Abstract:

Objective: To determine the maternal morbidity in pregnant women with acute hepatitis E viral infection. Study Design: Observational, cross-sectional study. Place and Duration of Study: Departments of Obstetrics and Gynaecology and Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Red Crescent General Hospital and Saint Elizabeth Hospital, Hyderabad, from January 2011 to December 2013. Methodology: The study population was pregnant women with acute hepatitis E infection confirmed by ELIZA technique. Pregnant women with other hepatic viral infections were excluded. All medical and obstetric conditions, and mortality were noted on the predesigned proforma. Results: Out of the total 45 admitted pregnant women with hepatitis E viral infection, 22 women (48.9%) had severe morbidity. The most common were hepatic coma in 8 (36.36%) cases and disseminated intravascular coagulation in 14 (63.63%) cases. Highest mortality rate was seen in women with hepatic coma (100%), while in those with disseminated intravascular coagulation, one out of the 14 cases (7.14%) died. Conclusion: The acute viral hepatitis E infection in pregnant women is associated with maternal morbidities and high mortality rate.

Page(s): 734-737

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 25, Issue: 10, Year: 2015

Keywords:

Keywords are not available for this article.

References:

[1] LabriqueAB,SikderSS,KrainLJ,WestKP,ChristianP,RashidM, 2012.Hepatitis E, a vaccine-preventable cause of maternal deaths,Emerg Infect Dis 18 1401 -4

[2] PurcellRH,EmersonSU, 2008.Hepatitis E: an emerging awareness of an old disease,J Hepatol 48 494 -503

[3] AggarwallR, 2011.,Hepatology 54 2218 -26

[4] TaniguchiM,KimSR,MishroS,TakahashiK,ShinMH,YunH, 2009.Epidemiology of hepatitis E in north eastern China, South Korea and Japan,J Infect 58 232 -7

[5] GoumbaCM,Yandoko-NakouneER,KomasNP, 2010.A fatal case of acute hepatitis E among pregnant women, Central African Republic,BMC Research Notes 3 103 -

[6] AggarwallR., 2011.Clinical presentation of hepatitis E,Virus Res 161 15 -22

[7] BhatiaV,SinghalA,PandaSK,AcharyaSK, 2008.A 20 years single centre experience with acute liver failure during pregnancy: is the prognosis really worse,Hepatology 48 1577 -85

[8] RayisDA,JumaaAM,GasimGI,KarsanyMS,AdamI., 2013.An outbreak of hepatitis E and high maternal mortality at Port Sudan, Eastern Sudan,Pathog Glob Health 107 66 -8

[9] KhurooMS, 2011.Discovery of hepatitis E: the epidemic non-A, nonB, hepatitis 30 years down the memory lane,Virus Res 161 3 -14

[10] RenouC,GobertV,LocherC,MoumenA,TimbelyO,SavaryJ, 2014.Prospective study of hepatitis E virus infection among pregnant women in France,Virol J 11 11 -68

[11] ZhuFC,ZhangJ,ZhangXE,ZhouC,WangZZ,HaungSJ, 2010.Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double blind placebo-controlled phase 3 trial,Lancet 376 895 -902

[12] ZhangJ,ShihJW,XiaNS, 2015.Long-term efficacy of a hepatitis E vaccine,N Engl J Med 372 914 -22

[13] LindemanML,GabilondoG,RomeroB,MazaOM,GraciaMT, 2010.Low prevalence of hepatitis infection among pregnant women in Madrid, Spain,J Med Virol 82 1666 -8

[14] VelosaM,FigueiredoA,GloriaH,MorbeyA,MateusE, 2013.Fulminant hepatitis E in a pregnant women,GE J Port Gastrenterol 20 210 -4

[15] PatraS,KumarA,TrivediSS,PuriM,SarinSK, 2007.Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection,Ann Intern Med 147 28 -33

[16] SinghR,SinghMM,HazraDK,AgarwalN,PatneyNL,GoyalSP, 1983.A study of disseminated intravascular coagulopathy in hepatic coma complicating acute viral hepatitis,Angiology 34 470 -9

[17] KhurooMS, 1980.Study of epidemic of non-A, non-B, hepatitis; possibility of another human hepatitis virus distinct from post transfusion non-A, non-B, type,Am J Med 68 818 -23

[18] BanaitVS,SandurV,ParikhF,MurugeshM,RankaP,RameshVS, 2007.Outcome of acute liver failure due to acute hepatitis E in pregnant women,Indian J Gastroenterol 26 6 -10

[19] TeoCG, 2012.Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E,Infection 140 767 -87

[20] NaikSR,AggrawalR,SalunkePN,MehrotraNN, 1992.A large waterborne hepatitis E epidemic in Kanpur, India,Bull World Health Organ 70 597 -604

[21] RenouC,MoreauX,ParienteA,CadranelJF,MaringeE,MorinT., 2008.A national survey of acute hepatitis E in France,Aliment Pharmacol Ther 27 1086 -93

[22] YasmeenT,HashmiHA,TajT., 2013.Fetomaternal outcome with hepatitis E in pregnancy,J Coll Physicians Surg Pak 23 711 -4

[23] SultanaR, 2014.Fetomaternal outcome in acute hepatitis E,J Coll Physicians Surg Pak 24 127 -30

[24] BoutrouilleA,Bakkali-KassimiL,CruciereC,PavloN., 2007.Prevalence of anti-hepatitis E virus antibodies in French blood donors,J Clin Microbiol 2009 -2010

[25] MansuyJM,BendallR,Legrand-AbravanelF,SauneK,MiedougeM,EllisV, 2011.Hepatitis E virus antibodies in blood donors,France. Emerg Infect Dis 17 2309 -12

Citations

Downloads

Views