Specrophotometric determination of Indomethacin using partial least Square Method. | Proceedings of Pakistan Academy of Sciences 2007

Author(s)

Fouzia Noreen Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

Amina Mumtaz Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

Saima Nazir Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

Tehseen Aman In-charge Research Cell, Kinnaird College, Lahore, Pakistan

Abstract

Indomethacin reacts with ammonium oxalate in concentrated sulphuric acid to give a violet colour after heating for 17 min at 80°C having maximum absorbance at 578 nm. The reaction is selective for indomethacin with a 0.05 mg/10 mL as visual limit of identification and provides a basis for a new spectrophotometric determination. The reaction obeys Beer`s Law from 0.05 mg to 4 mg/ 10 mL of indomethacin with inter-day precision of 0.98 %. The quantitative assessment of common interferences and tolerable amount of other drugs were also studied.

Publication Details

Page(s) 173-179

DOI DOI not available

Published Journal: Proceedings of Pakistan Academy of Sciences, Volume: 44, Issue: 3, Year: 2007

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