The association between the lymph node ratio, surgical margin, and survival in patients with colon cancer receiving adjuvant chemotherapy | [Pakistan Journal of Medical Sciences • 2022]

Author(s):

1. Evren Fidan: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

2. Elif Merev: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

3. Arif Usta: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

4. Celal Alandag: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

5. Safak Disli: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

6. Ali Ozdover: Department of Medical Oncology,Faculty of Medicine,Karadeniz Technical University, Trabzon, Turkey.

Abstract:

Objectives: To investigate the prognostic significant of lymph node ratio and surgical margins in patients with colon cancer undergoing surgery. Methods: This observational and retrospective study was conducted at Karadeniz Technical University Medical Faculty, between 1 January, 2010 and 31 November, 2020. A series of 137 patients who had undergone surgical resection of colon carcinoma were included in this study. mLNR, defi ned as the ratio of the number of mLNs to the number of examined lymph nodes, was calculated in colorectal cancer cases with lymph node metastasis. Patients were divided into three groups; LNR1 ( 0.6). Results: Mean disease-free survival was 79.2 months (95% CI 71.0-87.4). The mean expected survival time was 73.5 months (95% CI: 65.9-81.0). As the metastatic LN ratio increased, the rate of local recurrence or distant metastasis increased statistically significantly (p=0.007). As the metastatic LN ratio increased, the death rate increased statistically significantly (p=0.036). Metastatic lymph node ratio did not have a statistically significant effect on overall survival in patients with stage-3 and more than 12 LNs removed (p=0.069). There was no statistically significant association between the closeness of the surgical margin and disease-free survival in stage 1 (p=0.505) and stage-2 (p=0.161). There was no statistically significant association between the closeness of the surgical margin and overall survival among patients with stage 1 (p=0.494) and stage 2 (p=0.265). Conclusion: A high metastatic LNR is associated with poorer overall and disease-free survival.

Page(s): 605-611

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 38, Issue: 3, Year: 2022

Keywords:

Lymph nodes , Colon cancer , surgical margins

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