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Unlocking the Medicinal Potential of Sarcococca saligna: Green Synthesis of Silver and Gold Nanoparticles for Enhanced Antibacterial and Antifungal Applications
Author(s):
1. Sabi Ur Rehman: Department of Pharmacy, Faculty of Natural Sciences, Forman Christian College (A Chartered University),Lahore, 54600,Pakistan
2. Laiba Arshad: Department of Pharmacy, Faculty of Natural Sciences, Forman Christian College (A Chartered University),Lahore, 54600,Pakistan
3. Saman Ali: Department of Pharmacy, Faculty of Natural Sciences, Forman Christian College (A Chartered University),Lahore, 54600,Pakistan
4. Shazma Massey: Department of Chemistry, Faculty of Natural Sciences, Forman Christian College (A Chartered University),Lahore, 54600,Pakistan
5. Safeer Khan: Department of Pharmaceutical Sciences, Institute of Chemical Sciences, Government College University,Lahore,Pakistan
6. Abdul Samad: Food Science Research Institute, National Agriculture Research Center,Islamabad,Pakistan
7. Fazal-Ur-Rehman: Faculty of Pharmacy, Gomal University,Dera Ismael Khan,Pakistan
Abstract:
| A notable advancement in nanotechnology is the eco-friendly and cost-eficient production of metal nanoparticles utilizing botanical extracts. Silver nanoparticles are particularly noteworthy due to their potent antibacterial properties and relevance in nanomedicine. This study presents a green synthesis method using Sarcococca saligna leaf extracts to successfully produce both silver and gold nanoparticles. The formation and stability of the nanoparticles were verified through a change in physical colour and characterized using Ultraviolet-Visible spectroscopy and Scanning Electron Microscopy. Antibacterial and antifungal activity assessments revealed moderate eficacy against Candida albicans, Staphylococcus aureus and Escherichia coli, comparable to Amoxicillin and Fluconazole. Further discussion explores the antibacterial efects of Ag NPs, highlighting their potential applications in combating bacterial infections. These findings underscore the significance of green synthesis methods in nanoparticle production and their potential roles in various fields, including medicine and biotechnology.
Page(s): 327-334
Published: Journal: Pakistan Journal of Agricultural Research, Volume: 36, Issue: 4, Year: 2023
Keywords:
Medicinal plants , Silver nanoparticles , Gold nanoparticles , Sarcococca saligna , Antibacterial assay , Antifungal assay
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