Tissue cytokine adenoid experssion in hypertrophic adenoid gland in children with allergic rhinitis | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2021]

Author(s):

1. Fengjuan Zhu: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China; Department of Otolaryngology-Head and Neck Surgery, The People’s Hospital of Rizhao,126 Taian Road,Rizhao

2. Kaiyue Sun: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China

3. Liang Yu: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China

4. Shujuan Sun: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China

5. Yuzhu Wan: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China

6. Li Shi: Department of Otolaryngology - Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China

Abstract:

Objective: To investigate the in ammatory pattern in terms of in ammatory cells and cytokines expression in children with adenoid hypertrophy (AH) and coexistent allergic rhinitis (AR). Study Design: A cross-sectional analytical study. Place and Duration of Study: Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong P. R. China, from October 2018 to August 2020. Methodology: A sample of 102 children with AH, who underwent adenoidectomy were enrolled. They were divided into two groups of AH, alone and AH with AR (AH+AR). A routine complete blood count, and the number of eosinophils in adenoid tissue was measured using hematoxylin-eosin staining. The tissue expression of cytokines was carried out using real-time quantitative PCR. Results: Forty-eight children (47%) were diagnosed with AR. The number and percentage of eosinophils in peripheral blood and adenoid tissue were statistically (p <0.05) higher in the group of AH+AR than AH alone. Furthermore, in patients with AH+AR, the mRNA expression levels of IL-12 and IFN-³ decreased, while IL-4, IL-8, IL-18, IL-33, H2R, LTR1, LTR2 and GCR all increased in adenoid tissue. Conclusion: The pathological mechanism underlying adenoid hypertrophy in children with comorbid allergic rhinitis can be involved with predominant tissue eosinophilia and type 2 (or Th 2) in ammation.

Page(s): 903-909

DOI: 10.29271/jcpsp.2021.08.903

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 31, Issue: 8, Year: 2021

Keywords:

allergic rhinitis , Cytokines , Eosinophils , Adenoid hypertrophy , In ammatory features

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