The impact of hormone receptor status on survival and recurrence of HER2-positive breast cancers in standard adjuvant setting: A retrospective study in Tehran, Iran | [Journal of Pakistan Medical Association • 2020]

Author(s):

1. Safa Najafi: Department of Breast Diseases, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

2. Masoud Sadeghi: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

3. Mohammad Reza Shajari: Department of Breast Diseases, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

4. Fatemeh Abasvandi: Department of Breast Diseases, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

5. Kamran Mohebi: Department of Breast Diseases, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Abstract:

Objective: To evaluate hormone receptor status on survival and recurrence of the human epidermal growth factor receptor 2-positive breast cancer treated with Trastuzumab in the adjuvant setting. Methods: The retrospective study was conducted in 2017 at the Breast Cancer Research Centre, Tehran University of Medical Sciences, Tehran, Iran, and comprised data of women aged >20 years with stage I-III of human epidermal growth factor receptor 2-positive breast cancer who were treated with Trastuzumab from 2008 to 2017. The patients were divided into two groups. Group P had patients who were triple positive for human epidermal growth factor receptor 2, oestrogen receptor and progesterone receptor. Group N had patients positive for only human epidermal growth factor receptor 2. All patients in group P were treated with hormone therapy. Overall survival, disease-free survival, and distant metastasis rates were measured. SPSS 22 was used for data analysis. Results: Of the 263 patients, 169(%) were in group P with a mean age of 46.86 ± 10.92 years, and 94(%) were in group N with a mean age of 48.53±12.33 years (p>0.05). There were no unfavourable predictors for overall survival and disease-free survival except for stage (p<0.05). The difference on both counts between the groups was not significant (p>0.05 each). Conclusion: The impact of hormone receptor positivity on survival and progression of human epidermal growth factor receptor 2-positive breast cancer remains an area of debate.

Page(s): 11-16

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 70, Issue: 1, Year: 2020

Keywords:

Breast cancer , Survival , Hormone receptor , HER2 , Trastuzumab

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