Author(s):
1. Zeeshan Ayub:
Combined Military Hospital Quetta/National University of Medical Sciences (NUMS), Pakistan
2. Ahmed Hasan Ashfaq:
Combined Military Hospital Quetta/National University of Medical Sciences (NUMS), Pakistan
3. Amir Ali Khan:
Combined Military Hospital Quetta/National University of Medical Sciences (NUMS), Pakistan
4. Kamran Ashfaq Ahmed Butt:
Combined Military Hospital Quetta/National University of Medical Sciences (NUMS), Pakistan
Abstract:
Objective: To evaluate vertigo control and auditory rescue in patients with Meniere's disease treated with intratympanic Gentamicin and Dexamethasone. Study Design: Randomized Control Trial (Clinical Trials. gov Identifier: NCT05355610). Place and Duration of Study: ENT Departments CMH Quetta and Benazir Bhutto Hospital Rawalpindi Pakistan from Apr 2020 to Mar 2022. Methodology: Ninety-three cases of unilateral Meniere's disease meeting the inclusion criteria were treated with intratympanic Gentamicin and Dexamethasone. Pre and post-treatment vertigo was assessed on Vestibular Deficit Index. Speech discrimination scores for auditory impact were also recorded pre and post-treatment. Results: In the Ninety-three treated cases, there was a statistically significant improvement in the Vestibular Deficit Index (with a p-value of 0.001). Although all patients had a reduced speech discrimination score, it was not statistically significant (p value=0.08). Conclusion: Control of vestibular symptoms can be achieved with intratympanic Gentamicin, and at the same time, the auditory system can be rescued with Dexamethasone.
Page(s):
1444-1447
Published:
Journal: Pakistan Armed Forces Medical Journal, Volume: 72, Issue: 4, Year: 2022
Keywords:
Dexamethasone
,
Gentamicin
,
Intratympanic
References:
References are not available for this document.
Citations
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