A biospectroscopic and bioimaging analysis of imatinib nanoparticles aggregation linked to DNA/RNA by BCR-ABL tyrosine-kinase inhibitors (TKI) with various chain length | [Science International • 2020]

Author(s):

1. Alireza Heidari: Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA; American International Standards Institute, Irvine, CA 3800, USA

Abstract:

GRAPHICAL ABSTRACT : Imatinib nanoparticles show a strong peak of Plasmon absorption in ultraviolet-visible zone. A strong interaction exists between the surface of Imatinib nanoparticles and different Bcr-Abl tyrosine-kinase inhibitors (TKI) compounds.Different Bcr-Abl tyrosine-kinase inhibitors (TKI) compounds cause to aggregation of Imatinib nanoparticles linked to DNA/RNA and hence, lead to widening of peak Plasmon of Imatinib nanoparticles surface at 760 (nm) and emerging a new peak at higher wavelengths. In the current project, this optical characteristic of Imatinib nanoparticles is used to time investigate of interaction between different Bcr-Abl tyrosine-kinase inhibitors (TKI) and Imatinib nanoparticles. The results were shown that different Bcr-Abl tyrosine-kinase inhibitors (TKI) compounds with shorter chain length interact faster with Imatinib nanoparticles. Therefore, a simple and fast method for identification of Bcr-Abl tyrosine-kinase inhibitors (TKI) with various chain length using red shift in surficial Plasmon absorption is presented.

Page(s): 459-482

DOI: DOI not available

Published: Journal: Science International, Volume: 32, Issue: 4, Year: 2020

Keywords:

Aggregation , DNARNA , Peak Plasmon Absorption , Imatinib Nanoparticles , BcrAbl TyrosineKinase Inhibitors TKI

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