Vegetative part of nigella sativa L. potential antineoplastic sources against Hep2 and MCF7 human cancer cell lines | [Abstract Book on Second International Conference on Recent Approaches in Plant Sciences (RAPS-23) 4-5 May 2023 • 2023]

Author(s):

1. Arusa Aftab: Department of Botany, Lahore College for Women University Lahore, Pakistan

2. Z. Yousaf: Department of Botany, Lahore College for Women University Lahore, Pakistan

3. Zill-e-Huma Aftab: Department of Plant Pathology, University of the Punjab, Lahore, Pakistan

4. Zainab Maqbool: Department of Botany, Lahore College for Women University Lahore, Pakistan

5. Z. Shahzadi: Department of Botany, Lahore College for Women University Lahore, Pakistan

Abstract:

Cancer, a global health problem due to its increasing prevalence coupled with high mortality rate. Chemotherapy is an aggressive form of drug therapy. Herbal therapy is safer and healthier to treat specific ailments. Nigella sativa has been used as traditional medicine for centuries. The crude oil extracted from seed is effective against diseases but vegetative part of N. sativa has always been ignored for its therapeutic potential. It was hypothesized that vegetative part could be potential antineoplastic source against cancer. Therefore, reactive oxygen species determination and antineoplastic activity were performed against Hep2 and MCF7 cancer cell lines. n-butanol extract of Vegetative Part (VP) caused maximum cell death of Hep2 (58% cell viability). The chloroform VP extract showed 38% cell viability at 10 mg mL-1. The extracts with significant activity were later on validated through GCMS and LC-MS, following literature in PubChem, NIST and Spectrabase libraries.

Page(s): 166-166

DOI: DOI not available

Published: Journal: Abstract Book on Second International Conference on Recent Approaches in Plant Sciences (RAPS-23) 4-5 May 2023 , Volume: 0, Issue: 0, Year: 2023

Keywords:

Nigella sativa , cancer , cytotoxicity , Antineoplastic

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