Acrosomal vesicle protein in predicting progression of pancreatitis in Chinese patients with acute pancreatitis | [Pakistan Journal of Pharmaceutical Sciences • 2022]

Author(s):

1. Ruting Zhao: Department of gastroenterology, No 31694 budui hospital,Benxi, Liaoning,China

2. Ruihong Ma: Department of gastroenterology, Benxi Iron and Steel Co. General Hospital,Benxi, Liaoning,China

3. Yunbo Zhao: Department of gastroenterology, No 31694 budui hospital,Benxi, Liaoning,China

4. Qinglong Zhang: Department of gastroenterology, No 31694 budui hospital,Benxi, Liaoning,China

5. Xianyu Hua: Department of gastroenterology, No budui hospital,Benxi, Liaoning,China

Abstract:

The present preliminary investigation was designed to identify biomarkers in the progression of pancreatitis in Chinese patients with acute pancreatitis. Chinese patients aged <60 years with a confirmed diagnosis of acute pancreatitis were enrolled. A saliva sample was collected using salimetrics oral swab in precooled polypropylene tubes to prevent degradation of sensitive peptides. All samples were then centrifuged at 700 × g for 15?min at 4°C to remove debris. The supernatant of each sample was fractionated into 100µL aliquots and frozen at -70°C until analyses using affymetrix HG U133 Plus 2.0 array technique. Bedside index for severity acute pancreatitis (BISAP) score and CT severity index were recorded for each enrolled patient to assess the progression and severity of acute pancreatitis. Data from a total of 210 patients (105 patients in each group) were analyzed. Among identified biomarkers, acrosomal vesicle protein 1 was significantly higher in patients with disease progression as compared to patient without disease progression. Logistic regression model showed that acrosomal vesicle protein 1 (ACRV1) were positively correlated with the progression of diseases. The present reports showed that a mRNA salivary biomarker (ACRV1) are associated with progression of pancreatitis in patients with early stage of pancreatitis. This study suggest that mRNA salivary biomarker (ACRV1) is a predictor of pancreatitis progression.

Page(s): 1787-1791

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 35, Issue: 6, Year: 2022

Keywords:

Acute Pancreatitis , Biomarkers , acrosomal vesicle protein 1

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