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The relationships between 7-kchol, 7β-ohchol, chol-triol, Lp (A) and PON1 with coronary heart disease in patients with diabetes mellitus T1DM and T2DM
Author(s)
Ahmed Mohammed Ahmed Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Omar F Khabour Department of Medical Laboratory Sciences, Jordan University of Science and Technology,Irbid,Jordan
Amjad Yousuf Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Walaa Mohammedsaeed Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Nawaf Fawaz Alahmadi Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Ahmad Mahmood Alshangeety Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Omar Howadi Alotaibi Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Amer Abdullah Alhaidary Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University,Madinah KSA,
Abstract
Oxysterols (OXY) are oxidized derivatives of cholesterol associated with oxidation and can increase the risk of cardiovascular diseases. The aim of the current study is to examine the relationships between OXY profile, lipids, lipoprotein(a) [Lp(a)] and paraoxonase1 (PON1) with coronary heart disease (CHD) in patients with diabetes mellitus type1 (T1DM) and type2 (T2DM). 120 diabetic patients (T1DM=40, T2DM=80) and 60 healthy subjects were recruited in the study. OXY profile (7-KChol, 7ß-OHChol and Chol-triol) was measured using liquid chromatography-mass spectrometry. The clinical profile of the study participants was also collected. 7-KChol, 7ß-OHChol and Chol-triol and Lp(a), FBG and glycation parameters were higher in diabetic patients compared to controls (p<0.01), whereas PON1 was lower in patients compared to controls (p<0.01). Within the T2DM group, 7-KChol and 7ß-OHChol levels were associated with CHD, obesity, and smoking (p<0.05). In addition, KChol, 7ß-OHChol and Chol-triol levels were associated with smoking in T1DM (p<0.05). In both diabetic types, 7-KChol, 7ß-OHChol and Chol-triol were significantly correlated with TC, LDL, ApoB and Lp(a), glycation parameters and inversely with PON1 (p<0.05). OXY profile in diabetic patients can be used as a reliable biomarker of CHD, particularly in T2DM.
Publication Details
Page(s) 761-768
DOI DOI not available
Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 35, Issue: 3, Year: 2022
Keywords
type 2 diabetes mellitus Type 1 diabetes mellitus Oxysterols 7ketocholesterol 7ßhydroxycholesterol triol
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