Add-On Therapy of Dapagliflozin to Metformin in Patients with Diabetes Mellitus Type-2; Efficacy and Renal Safety | [Pakistan Armed Forces Medical Journal • 2023]

Author(s):

1. Benish Adil: Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Pakistan

2. Arshad Rabbani: Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Pakistan

3. Imran Arshad: Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Pakistan

4. Sualeha Ahmed: Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Pakistan

5. Muhammad Ali Khalid: Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Pakistan

Abstract:

Objective: To study efficacy of Dapagliflozin in treatment of diabetes mellitus type-2. Study Design: Quasi-experimental study. Place and Duration of Study: Medical unit, Benazir Bhutto Shaheed Hospital, Rawalpindi Pakistan from Jan to Dec 2019. Patients & methods: Patients taking Dapagliflozin in combination with Metformin (MET+DAPA) (n=45) were compared to those taking other glucose lowering agent in combination with Metformin (MET+ other drug) (n=45) for the control of diabetes mellitus type-II. Efficacy of treatment was assessed by the level of glycosylated hemoglobin HbA1c, and renal safety assessed by serum creatinine level done at 6 and 12 months of treatment. Results: Total 90 cases were studied including 60% male and 40% female cases with mean age 50.8±7.4 years. Patients taking Dapagliflozin + Metformin (n=45), and others taking Metformin+ other glucose lowering drug (n=45) were having mean values of BMI 32.8±5.9 kg/m2 & 33.4±7.2 kg/m2, HbA1c 8.4±1.2% & 9.1±1.6 % and blood urea nitrogen 6.7±1.4 & 6.5±1.8 mmol/L respectively. After 12 months treatment mean HbA1c level was reduced from 8.7 ± 1.4% to 6.6 ± 0.3%, BMI reduced significantly and no detrimental effects reported on renal function. Conclusion: Patients with type-II diabetes mellitus taking Dapagliflozin in combination with Metformin showed good glycemic control and renal safety.

Page(s): 148-151

DOI: 10.51253/pafmj.v73iSUPPL-1.4642

Published: Journal: Pakistan Armed Forces Medical Journal, Volume: 73, Issue: S1, Year: 2023

Keywords:

metformin , glycosylated hemoglobin , Diabetes mellitus type2 , Dapagliflozin

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