Abstract:
Objective: To investigate the e ects of clinicopathological features on disease-free survival (DFS) and overall survival (OS) in in-patients with local advanced rectal cancer (LARC) who received neoadjuvant chemoradiotherapy (nCRT). Study Design: Observational study. Place and Duration of Study: Clinic of Radiation Oncology, Kayseri Training and Research Hospital and Kayseri City Hospital, Turkey, between January 2014 and June 2019. Methodology: The pre-nCRT, post-nCRT, and postoperative imaging methods of 51 patients, who were operated upon, were examined. Radiological images (CT and MRI) of the patients were reviewed using the hospital s PACS system. Pathology reports and preparations were re-evaluated, and TNM staging and the pathological tumour regression grade (pTRG) were graded according to the American Joint Committee on Cancer s (AJCC) 2018 version. For the descriptive statistics of the data, the mean, standard deviation, lowest highest median, frequency, and ratio values were used. Cox regression (univariate multivariate analysis) and Kaplan Meier curves were used for survival analysis. Results: In the univariate model, the postoperative pathological T and N stages (ypT and ypN), pathological stage, positive lymph node count (pLN+, pathological sampling) andlymphovascular invasion (LVI) positivity had a signi cant e ect (p <0.05) on DFS. In the multivariate reduced model, a signi cant independent (p <0.05) e ect of the ypT and pLN+ number was observed on DFS. In the univariate model, the pathological tumour diameter after nCRT, the ypT, perineural invasion (PNI) positivity, and relapse presence had a signi cant e ect p( <0.05) on OS. In the multivariate reduced model, a signi cant independent (p <0.05) e ect of recurrence was observed on OS. Conclusion: LVI, the ypTN stage, and the pLN+ number a ected the disease-free survival, while theresidual tumour diameter after nCRT, ypT stage, and PNI a ected the overall survival. The predicted DFS time decreased as the ypT stage increased and the predicted OS time decreased as the recurrence increased.
Page(s):
422-428
DOI:
DOI not available
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 31, Issue: 4, Year: 2021
Keywords:
overall survival
,
Neoadjuvant chemoradiotherapy
,
Diseasefree survival
,
Rectal cancer