Synthesis, Crystal Structure and Anticancer Activity of Substituted Quinazoline Derivatives | [Journal of Chemical Society of Pakistan • 2021]

Author(s):

1. Bo Wang: School of Petrochemical Engineering, Shenyang University of Technology,111003, Liaoyang, PR China

2. Zhi-qiang Cai: School of Petrochemical Engineering, Shenyang University of Technology, 111003, Liaoyang, PR China

3. Xiao-yu Shi: Key Laboratory for Chemical Drug Research of Shandong Province, Instiitute of Phamaceutical Sciences of Shandong Province, Shandong, PR China.

4. Xiang Li: Shenyang Photosensitive Chemical Research Institute Co. Ltd. Shenyang 110141, PR China.

5. Shuai Li: Key Laboratory for Chemical Drug Research of Shandong Province, Instiitute of Phamaceutical Sciences of Shandong Province, Shandong, PR China.

6. Ji-xin Li: School of Petrochemical Engineering, Shenyang University of Technology, 111003, Liaoyang, PR China.

Abstract:

Summary: News series of substituted quinazoline derivatives has been synthesized from 3,4-dihydro7-methoxy-4-oxoquinazoline-6-yl acetate (1) by five-step procedures including chlorination, amination, hydrolysis and etherification. The structures of target compounds were confirmed by IR, 1H-NMR, element analysis and single-crystal X-ray diffraction. The results showed that the compound 8c exhibited remarkable inhibitory activity against MCF-7 cell lines with inhibition rate value of 38.45 %, which was comparable to that of the positive control Gefitinib (inhibition rate = 13.25 % for MCF-7). The initial relationship between structure and activity was worth further exploration.

Page(s): 466-474

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 43, Issue: 4, Year: 2021

Keywords:

Xray Diffraction , Crystal structure , synthesis , anticancer activity , Quinazoline

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