The role of skin and gut microbiome in atopic dermatitis | [Journal of Pakistan Association of Dermatologists • 2022]

Author(s):

1. Menul Ayu Umborowati: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia; Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia.

2. Nurdini Wilda Salsabila: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia.

3. Damayanti: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia.

4. Sylvia Anggraeni: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia; Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia

5. Cita Rosita Sigit Prakoeswa: Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia.

Abstract:

In the last decade, there has been an increase case of atopic dermatitis (AD) worldwide. AD is a type of disease with chronic inflammation of the skin characterized by mild to severe itching, recurrent, and mostly occurred in infancy and childhood. There were some substantial data of patients with AD that have been disturbed and less diverse skin and gut microbes than healthy individuals. In the skin microbiome, AD is known to possess a larger percentage of Staphylococcus aureus(S. aureus)than healthy individuals. In addition, the population of Staphylococcus aureus, Clostridium difficile, and Escherichia coliin the gastrointestinal tract of patients with AD is higher than normal individuals, whereas the population of Bifidobacteria, Bacteroidetes, and Bacteroidesare experiencing a decrease. The AD will be prevented or treated if there is a balance in the skin and gut microbiome. It seems to underlie the benefit of probiotic in AD management

Page(s): 148-155

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 32, Issue: 1, Year: 2022

Keywords:

Gut microbiota , Atopic dermatitis , Probiotic , skin microbiota , human and health

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