Usefulness of white blood cell count to mean platelet volume ratio in the prediction of SYNTAX score in patients with non-ST elevation myocardial infarction. | [Pakistan Journal of Medical Sciences • 2019]

Author(s):

1. Serkan Sivri: Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

2. Erdogan Sokmen: Department of Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

3. Mustafa Celik: Department of Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

4. Sinan Cemgil Ozbek: Department of Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

5. Alp Yildirim: Department of Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

6. Yalcin Boduroglu: Department of Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

Abstract:

Objective: White blood cell (WBC) count to mean platelet volume (MPV) ratio (WMR) is associated with major adverse cardiovascular events in patients with non-ST elevation myocardial infarction (NSTEMI). We aimed to compare WMR between NSTEMI patients and matched-controls and to evaluate its predictive value on SYNTAX score. Methods: Total 175 patients with NSTEMI and 160 age and co-morbidity matched subjects were recruited in our study. WMR was compared between the patient and control groups. The patient group was further subdivided into 3 tertiles according to SYNTAX scores as follows: low SYNTAX score tertile (score =22, 141 patients); intermediate SYNTAX score tertile (score between 23 and 32, 20 patients); and, high SYNTAX score tertile (score =33, 14 patients). WMR was further assessed among the tertiles. Results: WMR was significantly greater in the patient group compared to the control group (p960 predicted a SYNTAX score =23 with 80.6% sensitivity and 67.6% specificity (AUC: 0.756; 95% CI: 0.685 - 0.818; p 1360 predicted a SYNTAX score =33 with 71.4% sensitivity and 93% specificity (AUC: 0.840; 95% CI: 0.777 - 0.892; p <0.0001). Conclusions: WMR value was significantly elevated in NSTEMI patients, compared to controls. Higher WMR was associated with greater SYNTAX score in patients with NSTEMI. WMR may be used to predict severity of the CAD and to implement risk stratification in patients with NSTEMI.

Page(s): 824-829

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 35, Issue: 3, Year: 2019

Keywords:

White blood cell count to mean platelet volume ratio

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