Autoimmune Polyglandular Syndrome Type-1 | Pakistan Paediatric Journal 2018

Author(s)

ATTIA BARI Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

NADIA SADAQAT Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

SANA MEHREEN Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

Muhammad Nayyab Tahir Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

Iqbal Bano Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

Uzma Jabeen Department of Pediatric Medicine, The Children’s Hospital & the Institute of Child Health, Lahore, Pakistan

Abstract

Autoimmune Polyglandular syndrome type-1 (APS-1) also known as autoimmune polyendocrinopathy candidiasis and ectodermal dysplasia (APECED) is a rare hereditary autosomal recessive disorder that results from immune dysregulation caused by mutation in the AIRE gene. The classic clinical features in affected individuals are: Addison's disease, hypoparathyroidism, chronic mucocutaneous candidiasis and ectodermal dysplasia. For a patient to be diagnosed as APECED at least two of these features are required and the third feature may develop as the disease progresses. We report a case of a 4-year-old boy who presented with a history of failure to thrive, seizures, altered sensorium and had these episodes from last few months. Patient was diagnosed to have Addison's disease, hypoparathyroidism together with the manifestations of nails dystrophy and tooth enamel hypoplasia. A diagnosis of APECED was made. We did not have the facility for genetic analysis of the AIRE gene mutation. Individual disease components were managed accordingly.

Publication Details

Page(s) 213-216

DOI DOI not available

Published Journal: Pakistan Paediatric Journal, Volume: 42, Issue: 3, Year: 2018

Keywords

autoimmune Candidiasis Hypoparathyroidism polyendocrinopathy ectodermal dystrophy

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