A review of the available remedial procedures for the treatment of fatty liver disease | [Pakistan Journal of Medical and Health Sciences • 2020]

Author(s):

1. DELARAM ESKANDARI: Department of endocrinology, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences.,Tehran,Iran

2. NILOOFAR KHODABANDEHLOO: School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences.,Tehran,Iran

3. HOSEIN SAMADANIFARD: Department of endocrinology, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences.,Tehran,Iran

4. AMIR ZIAEE: Institute of endocrinology and metabolism, Iran University of Medical Sciences.,Tehran,Iran

5. ALIREZA HEJRATI: Department of Internal Medicine, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences.,Tehran,Iran

Abstract:

Fatty liver disease (FLD), known as a common cause of chronic liver disease globally, refers to a spectrum of disease-causing lipid accumulation in the liver. There are two types of FLD, including Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty Liver Disease (NAFLD). The pathological spectra of these two diseases are similar TO a range of conditions from steatosis to cirrhosis and hepatocellular carcinoma. The diagnosis of FLD relays highly on clinical suspicion, laboratory tests, or diagnostic techniques. Despite advancements in understanding the pathophysiology of FLD, targeted therapies for the disease are still absent. Abstinence, nutritional support, and medications such as corticosteroids and pentoxifylline are used for the management of patients with ALD. The treatment modality for patients with NAFLD is mainly based on weight loss and adjutant management using specific agents such as Insulin sensitizers and Anti-oxidants and cytoprotective therapies. The aim of this study is to provide a thorough review of the current therapies and strategies regarding the management of ALD and NAFLD.

Page(s): 1292-1300

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 2, Year: 2020

Keywords:

NonAlcoholic Fatty Liver Disease , Steatosis , alcoholic liver disease , abstinence , Fatty liver disease

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