Alanine aminotransferase as a predictor of adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy | [Pakistan Journal of Medical Sciences • 2016]

Author(s):

1. Ali Ekiz: Department of Maternal-Fetal Medicine Unit,Kanuni Sultan Suleyman Training and Research Hospital,Istanbul, Turkey.

2. Basak Kaya: Department of Maternal-Fetal Medicine Unit,Kanuni Sultan Suleyman Training and Research Hospital,Istanbul, Turkey.

3. Muhittin Eftal Avci: Department of Maternal-Fetal Medicine Unit,Kanuni Sultan Suleyman Training and Research Hospital,Istanbul, Turkey.

4. Ibrahim Polat: Department of Maternal-Fetal Medicine Unit,Kanuni Sultan Suleyman Training and Research Hospital,Istanbul, Turkey.

5. Selin Dikmen: Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

6. Gokhan Yildirim: Department of Maternal-Fetal Medicine Unit,Kanuni Sultan Suleyman Training and Research Hospital,Istanbul, Turkey.

Abstract:

Objective: To evaluate the associations between adverse perinatal outcomes and serum transaminase levels at the time of diagnosis in patients with intrahepatic cholestasis of pregnancy. Methods: We performed a retrospective analysis of patients hospitalized for evaluation of intrahepatic cholestasis of pregnancy from January 2013 to June 2014 in a tertiary center. Seventy-one patients were divided into two groups according to the presence (Group I) or absence of adverse perinatal outcomes (Group II). Results: The mean aminotransferase levels and conjugated bilirubin levels at the time of diagnosis were significantly higher in Group I than in Group II. Receiver operating characteristic curve analysis revealed that the alanine aminotransferase level could predict adverse perinatal outcomes with 76.47% sensitivity and 78.38% specificity, and the cut-off value was 95 IU/L.Among patients with intrahepatic cholestasis of pregnancy, those with adverse perinatal outcomes were significantly older, had an earlier diagnosis, and had higher alanine aminotransferase levels. Using the 95-IU/L cut-off value, patients with intrahepatic cholestasis of pregnancy had a 3.54-fold increased risk for adverse perinatal outcomes. Conclusions:Patients with intrahepatic cholestasis of pregnancy and high alanineaminotransferase levels should be followed up for possible adverse perinatal outcomes.

Page(s): 418-422

DOI: 10.12669/pjms.322.9057

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 32, Issue: 2, Year: 2016

Keywords:

Pregnancy , Alanine aminotransferase , Adverse perinatal outcome , Intrahepatic cholestasis

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