Abstract:
This study was conducted ot investigate the in uence of ¼-opioid receptor ge(nOePRM1) A118G polymorphism on dosage of morphine in advanced liver cancer patients. Seventy patients with advanced liver cancer at Changyi People's Hospital, Shandong Province, China, were included from February 2019 to December 2020. The dosage of morphine in patients withOPRM1 A118G di erent genotypes was compared. Thirty patients (42.86%)were of AA genotype, 35 (50.00%) were AG genotype and 5 (7.14%) were GG genotype. There was a signi cant di erence in morphine dosage within the rst 24 hours in patients withAA, AG and GG genotypes (all p <0.001), and morphine dosage in patients with GG genotype was the highest. In conclusion, OPRM1 A118G genotype may a ect the dosage of morphine in advanced liver cancer patients. More dosages of morphine are needed for pain control in patients with G allele.
Keywords:
Morphine
,
Liver Cancer
,
Gene polymorphism
,
¼opioid receptor gene OPRM1