The effect of Benzo (a) pyrene on Glutathione S- transferase, Glutathione peroxidase in the liver and kidney of mouse Mus Musculus: | [Pakistan Journal of Medical Sciences • 2003]

Author(s):

1. Parichehr Hanachi: Department of Biomedical Sciences, Faculty of Medicine & Health Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2. Shamaan Na: Department of Biomedical Sciences, Faculty of Medicine & Health Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

3. Ramli J.: Department of Biomedical Sciences, Faculty of Medicine & Health Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

4. Arshad Jh: Department of Biomedical Sciences, Faculty of Medicine & Health Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

5. Syed Ma: Department of Biomedical Sciences, Faculty of Medicine & Health Science, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

Abstract:

The effect of benzo (a) pyrene (BaP) on the activities of glutathione S-transferase (GST) and glutathione peroxidase (GPx) and histology in the liver and kidney of the mouse, Mus musculus were investigated. Three treatment groups of mice (6 in each group) were injected with 200mg/kg BaP once a week. Groups 1,2 and 3 were sacrificed after two, four and eight weeks, respectively by cervical dislocation. Similarly three control groups of mice injected with corn-oil were sacrificed at week 2, week 4 and week 8. Sections of the liver and kidney of mice were stained with hematoxylin and eosin. The GST activity in the liver and kidney was significantly increased after two weeks compared to the control, group (P

Page(s): 197-202

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 19, Issue: 3, Year: 2003

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