Invivo comparative diuretic study of Cichorium intybus, Terminalia chebula and Punica granatum | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Hira Maaz1 Hira Maaz: Dept. of Pharmacognosy, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

2. Farzana Sadaf: Department of Pharmacognosy, University of Karachi, Pakistan

3. Laila Anwer Ali: Department of Pharmacognosy, University of Karachi, Pakistan

4. Syed Waleed Ahmed Bokhari: Dept. of Pharmacognosy, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

5. Muhammad Mohtasheemul Hasan: Dept. of Pharmacognosy, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

6. Safia Abidi: Dept. of Pharmacognosy, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Abstract:

Worldwide trend towards the utilization of natural plant remedies has created an enormous need for information about the properties and uses of the medicinal plant. Many indigenous medicines have been claimed to have diuretic effect in traditional medicine system. Medicine induced diuresis is beneficial in many life-threatening disease conditions such ascongestive heart failure, nephrotic syndrome, cirrhosis, renal failure, hypertension, and pregnancy toxaemia but due to some serious side effects their use is limited. Moreover,naturally occurring diuretics include caffeine in coffee, tea and cola, which inhibit Na+ reabsorption and alcohol in beer, wine inhibit secretion of ADH, proved to be very effective in promoting sodium excretion. In the present study ethanolic extracts of Cichorium intybus, Terminalia chebulaand Punica granatum were investigated for diuretic activity in Wister rats. The extracts were administered once orally at a dose of 400mg/kg. Furosemide (10mg/kg) was used as standard reference drug and distilled water was used as control. The onset of diuretic action of all three extracts observed with the Furosemide, produces onset of action after 1 hour of oral administration which reached its peak in 2-3 hours. All extracts showed a significant increase in urine volume. All three extracts exhibited significant diuretic activity when compare to saline treated group. However, the diuretic activity of Punica granatum (8.1±0.66***)extract was higher than that ofTerminalia chebula (7.66±2.67**)and Cichorium intybus (6.32±2.67*). It is concluded that Punica granatum exhibited pronounced diuretic effect.

Page(s): 253-253

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Cichorium intybus , Herbal Medicines , Diuretic activity , Terminalia chebulaand Punica granatum

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